Extreme population differences across Neuregulin 1 gene, with implications for association studies

association between neuregulin-1 gene variant ‎‎(rs2439272) and schizophrenia and its negative ‎symptoms in an iranian population

objective: although the etiology of schizophrenia is unknown, it has a significant genetic component. ‎a number of studies have indicated that neuregulin-1 (nrg1) gene may play a role in the ‎pathogenesis of schizophrenia. in this study, we examined whether the rs2439272 of nrg1 ‎is associated with schizophrenia and its negative symptoms in an iranian population.‎ method: rs2439272 was genotype...

Genetic Variation and Population Substructure in Outbred CD-1 Mice: Implications for Genome-Wide Association Studies

Outbred laboratory mouse populations are widely used in biomedical research. Since little is known about the degree of genetic variation present in these populations, they are not widely used for genetic studies. Commercially available outbred CD-1 mice are drawn from an extremely large breeding population that has accumulated many recombination events, which is desirable for genome-wide associ...

Association of interleukin-1 gene polymorphism with risk of gastric and colorectal cancers in an Iranian population

‎ Association Between Neuregulin-1 Gene Variant ‎‎(rs2439272) and Schizophrenia and Its Negative ‎Symptoms in an Iranian Population

Objective: Although the etiology of schizophrenia is unknown, it has a significant genetic component. ‎A number of studies have indicated that neuregulin-1 (NRG1) gene may play a role in the ‎pathogenesis of schizophrenia. In this study, we examined whether the rs2439272 of NRG1 ‎is associated with schizophrenia and its negative symptoms in an Iranian population.‎ Method: Rs2439272 was genotype...

Association between a Missense Polymorphism (rs3924999, Arg253Gln) of Neuregulin 1 and Schizophrenia in Korean Population

Neuregulin 1 (NRG1) is associated with the pathogenesis of schizophrenia through controlling activation and signaling of neurotransmitter receptors. Influence to schizophrenia development by the NRG1 gene may differ in individuals, and genetic polymorphism is one of the factors affecting their differences. Association between three single nucleotide polymorphisms (SNPs) (rs7014762, -1174 A/T; r...